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Matrixyl 3000 | CAS: Available Upon Request

CAS Number:
Available Upon Request
Chemical Classification:
Research peptide

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Matrixyl 3000 is a palmitoylated oligopeptide blend referenced in cosmetic-matrix research for its reported effects on procollagen expression and dermal remodeling markers. Blend composition and palmitoylation stoichiometry can differ between commercial preparations, so batch-specific characterization governs inter-study reproducibility more than with single-sequence peptides. Investigators apply the material in human dermal fibroblast collagen assays, reconstructed skin-equivalent models, and ELISA-based matrix-protein quantification under serum-deprived conditions. Supplied with COA and purity documentation appropriate to blend format; research use only.

CAS
Available Upon Request
Molecular Formula
Peptide Blend
Molecular Weight
N/A
Purity
≥95%
Appearance
White lyophilized powder
Storage
Store at -20°C

Analytical Documentation

COA✓ Available
LC-MS✓ Available
HPLC✓ Available
NMR✓ Available

Research Inquiry

Overview

Matrixyl 3000 is a cosmetic research peptide blend comprising palmitoyl-tripeptide-1 and palmitoyl-tetrapeptide-7, palmitoylated fragments designed to penetrate stratum corneum models and signal dermal fibroblasts in cosmetic matrix research. The tripeptide component mirrors GHK-related signaling motifs while the tetrapeptide modulates interleukin-related inflammatory gene expression in keratinocyte-fibroblast co-culture systems. Matrixyl 3000 enables investigation of palmitoylation-enhanced lipophilicity, skin penetration kinetics, and extracellular matrix gene regulation in dermatological science laboratories. As a defined blend rather than single sequence, it supports comparative studies with individual palmitoyl peptides in cosmetic formulation research. Supplied at ≥95% purity (Peptide Blend; N/A), this material supports controlled laboratory investigation under research-use-only conditions.

Mechanism of Action

Palmitoyl-tripeptide-1 stimulates collagen I, III, and fibronectin synthesis in fibroblast cultures through TGF-beta and AP-1 pathway modulation similar to matrikine signaling research. Palmitoyl-tetrapeptide-7 reduces IL-6 and IL-8 expression in UV-stressed keratinocyte models, attenuating paracrine inflammatory signals to dermal fibroblasts in co-culture. Palmitoyl chains anchor peptides into lipid bilayers of skin penetration models, increasing dermal delivery versus unpalmitoylated sequences in Franz cell research. Combined blend produces synergistic ECM remodeling readouts in cosmetic assay panels standardized by industry research groups.

Receptor Binding & Signaling

Matrixyl peptides act through matrikine-like cell surface signaling and cytokine receptor modulation rather than single GPCR targets. Palmitoyl-tetrapeptide-7 interferes with IL-1 mediated NF-kB activation in keratinocyte research. No melanocortin or GH receptor engagement at cosmetic research concentrations.

Research Applications

Fibroblast collagen synthesis assays

Human dermal fibroblasts treated with Matrixyl 3000 quantify procollagen I secretion, hydroxyproline content, and ECM protein immunostaining in research cultures. Individual peptide arms tested separately deconvolute blend contributions. Cosmetic matrix research platforms standardize these readouts.

Keratinocyte inflammatory co-culture

UV-irradiated keratinocytes co-cultured with fibroblasts use Matrixyl 3000 to measure IL-6 reduction and downstream collagen degradation enzyme expression. Palmitoyl-tetrapeptide-7 arm emphasized in cytokine-focused experiments. Research supports anti-photoaging hypothesis testing in vitro.

Skin penetration and Franz cell models

Excised skin Franz diffusion cells apply Matrixyl 3000 formulations to track peptide penetration into dermis by LC-MS in cosmetic science research. Palmitoylation compared with free peptides defines delivery enhancement. Formulation chemistry intersects peptide biochemistry.

Comparative palmitoyl peptide structure-activity

Head-to-head experiments contrast Matrixyl 3000 with GHK-Cu and other cosmetic peptides on standardized gene expression panels in fibroblasts. Blend ratio optimization studied in supplier research programs. Outputs inform cosmetic ingredient characterization.

Molecular Information

Sequence & Chain Summary

Blend: palmitoyl-Gly-His-Lys (tripeptide-1) and palmitoyl-Gly-Gln-Pro-Arg (tetrapeptide-7).

Modification Type

N-terminal palmitoylation on both peptide components.

Structural Notes

Palmitoyl chains increase lipophilicity and molecular weight heterogeneity, requiring specialized HPLC and MS methods for blend characterization. Matrixyl 3000 supplied as lyophilized blend at ≥95% combined purity per specification. Individual peptide identity confirmed by peptide mapping on COA. Batch-specific molecular characterization—including mass confirmation and purity profiling—is available through COA, LC-MS, HPLC, and NMR documentation supplied with Matrixyl 3000.

Molecular Formula
Peptide Blend
Molecular Weight
N/A
Purity Specification
≥95%

Experimental Notes

Stability

Store lyophilized blend at −20°C. Palmitoylated peptides aggregate in aqueous storage over time; reconstitute fresh for penetration assays. Protect from oxidative degradation during formulation research involving emulsifiers and antioxidants. Lyophilized Matrixyl 3000 should be protected from repeated freeze-thaw cycles, moisture, and prolonged exposure to ambient light where applicable. Analytical integrity is best preserved when material is stored under the conditions specified on the certificate of analysis.

Storage Conditions

Store at -20°C. Matrixyl 3000 is supplied as white lyophilized powder. For long-term archival storage in research inventories, maintain sealed containers with desiccant where recommended and document lot numbers for traceability across experimental runs.

Laboratory Handling

Reconstitute in cosmetic research vehicles compatible with cell culture or skin models. Sonication or gentle warming may aid solubilization of palmitoylated material. Document blend concentration in active peptide micrograms per milliliter. Reconstitute only with appropriate research-grade solvents compatible with your assay format. Allow vials to reach equilibrium before opening, work under clean bench conditions, and label all working solutions with concentration, date, and researcher ID per institutional SOPs.

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Frequently Asked Questions

Research-focused answers about Matrixyl 3000. For laboratory use only — not medical advice.

What is Matrixyl 3000 used for in research?
Matrixyl 3000 is for cosmetic science and dermatological matrix research in vitro and in skin model systems. Not for human cosmetic product claims validation without appropriate regulatory frameworks.
How does Matrixyl 3000 work biologically?
Matrixyl 3000 blend stimulates collagen synthesis via palmitoyl-tripeptide-1 and modulates keratinocyte inflammatory signaling via palmitoyl-tetrapeptide-7 in fibroblast-keratinocyte research models.
What receptors does Matrixyl 3000 interact with?
Matrikine-like ECM signaling and IL-1/NF-kB pathway modulation rather than single GPCR targets. Palmitoylation enhances membrane interaction without defining a unique receptor.
Is Matrixyl 3000 stable at room temperature?
Store lyophilized blend at −20°C. Palmitoylated peptides aggregate in aqueous storage over time; reconstitute fresh for penetration assays. Protect from oxidative degradation during formulation research involving emulsifiers and antioxidants. For short-term laboratory workflows, minimize time at room temperature and return unused material to recommended storage promptly. Matrixyl 3000 is not formulated for ambient long-term storage.
What is the recommended storage condition for Matrixyl 3000?
Store at -20°C. Store lyophilized material in a dedicated −20°C freezer, protect from moisture ingress, and avoid repeated temperature cycling. Reconstituted solutions should be aliquoted and frozen if not used within the validated window of your internal stability study.